Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis
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چکیده
منابع مشابه
Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis.
In multiple sclerosis, the immune system attacks the white matter of the brain and spinal cord, leading to disability and/or paralysis. Myelin, oligodendrocytes and neurons are lost due to the release by immune cells of cytotoxic cytokines, autoantibodies and toxic amounts of the excitatory neurotransmitter glutamate. Experimental autoimmune encephalomyelitis (EAE) is an animal model that exhib...
متن کاملSimultaneous neuroprotection and blockade of in ̄ammation reverses autoimmune encephalomyelitis
In multiple sclerosis, the immune system attacks the white matter of the brain and spinal cord, leading to disability and/or paralysis. Myelin, oligodendrocytes and neurons are lost due to the release by immune cells of cytotoxic cytokines, autoantibodies and toxic amounts of the excitatory neurotransmitter glutamate. Experimental autoimmune encephalomyelitis (EAE) is an animal model that exhib...
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Focal cerebral ischemia and traumatic brain injury induce an escalating amount of cell death because of harmful mediators diffusing from the original lesion site. Evidence suggests that healthy cells surrounding these lesions attempt to protect themselves by producing endocannabinoids (eCBs) and activating cannabinoid receptors, the molecular target for marijuana-derived compounds. Indeed, acti...
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Neurodegeneration is the irremediable pathological event occurring during chronic inflammatory diseases of the CNS. Here we show that, in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, inflammation is capable in enhancing glutamate transmission in the striatum and in promoting synaptic degeneration and dendritic spine loss. These alterations occur early in...
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Helmar Waiczies, Stefano Lepore, Jason M Millward, Bettina Purfürst, Thoralf Niendorf, and Sonia Waiczies Ultrahigh Field Imaging in Neuroinflammation, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Deutschland, Germany, Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for...
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ژورنال
عنوان ژورنال: Brain
سال: 2004
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awh156